Modulation of copper transporters in protection against cisplatin-induced cochlear hair cell damage
نویسندگان
چکیده
منابع مشابه
Ceramide-1-phosphate protection of cochlear hair cells against cisplatin ototoxicity
BACKGROUND Ceramide-1-phosphate (C1P) is a phosphorylated form of ceramide. While ceramide is known to be an inducer of apoptosis of cochlear hair cells in cisplatin ototoxicity, little is known about the function of C1P in cochlear diseases. PURPOSE The present study was designed to examine whether C1P could protect cochlear hair cells against cisplatin ototoxicity. MATERIALS AND METHODS E...
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The aim of the present study was to investigate the effects of Lycium barbarum polysaccharides (LBP) on cisplatin-induced hair cell damage in the organ of Corti explant. The neonatal (P2-3) rat organ of Corti explant was exposed to cisplatin (20 μM; 48 h) with or without LBP pretreatment (150 and 600 μg/mL; 24 h). Hair cell loss was indicated by FITC-labeled phalloidin staining. The level of re...
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As a relatively polar molecule, CDDP is thought to use specific plasma membrane systems for passage into cells, although entry by passive diffusion is also likely to occur. Alterations in these plasma membrane systems have been considered to be important resistance factors because one of the most consistent features of CDDP-resistant cell lines is decreased intracellular drug levels (1). Wherea...
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ژورنال
عنوان ژورنال: Journal of Otology
سال: 2011
ISSN: 1672-2930
DOI: 10.1016/s1672-2930(11)50022-4